Integration of spleen focus-forming virus proviruses in Friend tumor cells
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چکیده
منابع مشابه
Integration of spleen focus-forming virus proviruses in Friend tumor cells.
Using the Southern blot procedure, we studied the presumed spleen focus-forming virus (SFFV) provirus integration sites in the genome of the premalignant and the malignant cells isolated during the course of Friend erythroleukemia. Two restriction endonucleases, PstI and BamHI, discriminated the presumed integrated SFFV proviruses from the endogenous xenotropic-mink cell focus-forming viral seq...
متن کاملerythroleukemia virus - inducedstimulating factor genes in Friend spleen focus - forming
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متن کاملInduction of the early stages of Friend erythroleukemia with helper-free Friend spleen focus-forming virus.
The polycythemia-inducing strain of Friend virus (FV-P) causes a multistage erythroleukemia in susceptible mice. FV-P is a complex of two viruses, a replication-competent virus [Friend murine leukemia virus (F-MuLV)] and a replication-defective spleen focus-forming virus (SFFVp). We have addressed directly the role of SFFVp in the induction of the early stages of Friend disease by constructing ...
متن کاملFactors influencing the assay for target cells of Friend spleen focus-forming virus.
amounts of SFFV and of SFFV-induced tumor cells that were recovered at specified times after inoculation from the spleens of these mice represented the index of the presence of the target cells for replication of SFFV and for induction of tumor by SFFV. Five interrelated factors influenced the amounts of SFFV and SFFV-induced tumor cells that were recovered: (a) the concentrations of hemopoieti...
متن کاملRole of phosphatidylinositol 3-kinase in friend spleen focus-forming virus-induced erythroid disease.
Infection of erythroid cells by Friend spleen focus-forming virus (SFFV) leads to acute erythroid hyperplasia in mice due to expression of its unique envelope glycoprotein, gp55. Erythroid cells expressing SFFV gp55 proliferate in the absence of their normal regulator, erythropoietin (Epo), because of interaction of the viral envelope protein with the erythropoietin receptor and a short form of...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1985
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.53.1.292-295.1985